The purpose of this study was to investigate clinical features and prognosis of OMG with different phenotypes. THE INITIAL SYMPTOMS or signs of myasthenia gravis are ptosis, extraocular muscle weakness, or ocular misalignment in up to 65% of patients. Myasthenia gravis affects both men and women and occurs across all racial and ethnic groups. [23] Early thymectomy and administration of prednisolone can decrease relapse and secondary generalization of OMG. Search for Similar Articles Ocular myasthenia gravis is a type of myasthenia gravis (MG), that affects the eye muscles. Keyword Highlighting Limited studies demonstrated that patients presented with initial symptoms of only … Muscle Nerve 2010; 41:379. Ocular Myasthenia Gravis. Myasthenia gravis tends to progress in severity over a period of 3 years, following, which a patient either stabilizes or improves. Patients with initial bilateral ptosis can predict the presence of concurrent autoimmune disease. MG is an autoimmune disease where anomalous antibodies are produced against the naturally occurring acetylcholine receptors in voluntary muscles. However, the differences of clinical features including age of disease onset, gender, thymoma, as well as other autoimmune disease between various phenotypes of OMG remain unidentified. Ptosis and diplopia were the most common symptoms of ocular MG (OMG). 2008;273:10–4, 3. Myasthenia gravis (MG) is a rare, autoimmune neuromuscular junction disorder. Epub ahead of print. Also, the time and the first symptom of OMG generalization between the two groups also had no statistical significance. Last reviewed January 28, 2021. Register with us for free These patients were divided into two groups: Single ptosis or diplopia group (n = 43) and concurrence diplopia and ptosis group (n = 16) based on the initial symptoms of disease onset. Try again. IntroductIon Myasthenia gravis (MG) is an autoimmune neuromuscular disorder caused by anti‐acetylcholine receptor antibodies (AChR‐Abs) or other etiologies. Ocular myasthenia gravis (MG) is a disease of the neuromuscular junction resulting in hallmark variability in muscle weakness and fatigability. The mechanisms underlying why different presentations of ptosis and diplopia have different clinical features and prognosis remain unclear. Registered users can save articles, searches, and manage email alerts. Myasthenia gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. We use cookies to help provide and enhance our service and tailor content and ads. One can see that the symptoms of MG are not specific to the condition. Limited studies demonstrated that patients presented with initial symptoms of only ptosis in 47%, only diplopia in 14% and both ptosis and diplopia in 39% of OMG. [5] Th17 and Treg contributed to immunologic disorders in MG patients. Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China, Address for correspondence: Dr. Li-Li Wang, Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China E-Mail: [email protected]. the following symptoms: • weakness of the eye muscles (called ocular myasthenia) • drooping of one or both eyelids (ptosis) • blurred or double vision (diplopia) At 2 years, generalized myasthenia developed in 8 of 76 patients in the treated group and in 15 of 82 patients in the nonimmunotherapy group (odds ratio, 0.52; 95% confidence interval, 0.20–1.32). In addition, disequilibrium caused by treatment between the groups was precluded in order to assure the accuracy of this current analysis. Data is temporarily unavailable. To the best of our knowledge, there was no other related study reported. 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